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KMID : 0043320110340091527
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Archives of Pharmacal Research
2011 Volume.34 No. 9 p.1527 ~ p.1534
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The effect of quercetin-3-O-β-D-glucuronopyranoside on indomethacin-induced gastric damage in rats via induction of mucus secretion and down-regulation of ICAM-1 expression
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Yan Xiang Mei
Joo Min-jae
Lim Jae-Chun
Whang Wan Kyunn
Sim Sang-Soo
Im Chae-Uk
Kim Hak-Rim
Lee Seok-Yong
Kim In-Kyeom
Sohn Uy-Dong
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Abstract
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The mechanism of the protective effect of quercetin-3-O-β-D-glucuronopyranoside (QGC) from the leaves of Rumex aqauticus on indomethacin (IND, a representative NSAID)-induced gastric damage in rats was investigated. Pre-treatment with QGC significantly attenuated IND-induced gastric mucosal injury. An increase in myeloperoxidase (MPO) activity and expression of intercellular adhesion molecule (ICAM)-1 protein and mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin-1β, as well as a decrease in gastric mucus secretion were detected in the gastric mucosa of IND-treated rats. QGC reversed the side effect of IND on MPO activity and mucus production. Furthermore, QGC pre-treatment notably decreased ICAM-1 protein and mRNA expression of the pro-inflammatory cytokines, suggesting that QGC protection from IND-induced damage is associated with increased gastric mucus secretion, inhibition of free radical production by activated neutrophils via ICAM-1, and pro-inflammatory cytokine downregulation.
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KEYWORD
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Gastric damage, Mucus secretion, Intercellular adhesion molecule-1, Myeloperoxidase, Quercetin-3-O-β-D-glucuronopyranoside, Interleukin-1β, Tumor necrosis factor-α
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